Zona Laser Drill
Sperm Analyzer
Laser XY Clone
Live Cell Imaging
Special Slides
Veterinary Ventilator
IVF Application
XYClone is for non-clinical research use only in USA. hESC research using the XYClone should be conducted in accordance with any applicable Federal, State or local laws and regulations.

Please Note: The XYClone™ is for use ONLY with ANIMAL and STEM CELL APPLICATIONS.
(For Clinical Laser Assisted Hatching applications, please see the ZILOS-tk.)

The "Mercury Free"

Laser Ablator for Stem Cell Research, Gene Targeting, Knock Out Mouse Production, SCNT, ICSI, IVF and Assisted Hatching

No other system gives you the ease of use, flexibility and portability of the XYClone®

An Invaluable Tool for the Researcher

Reliably, quickly, and cleanly opens the zona for stem cell excision from blastocysts, nuclear transfer, and ICSI. Also, since no mercury is required, the entire process is safer, for both you and the embryo.

Plug & Play

Simply turn on the XYClone and you are ready to go! No warm-up time is needed.

Save Money on Supplies!

Unlike piezo drills, the XYClone is "non-contact" and requires no special needles or pipettes. So not only can you achieve your results quickly and reliably, but you also save money.

Hands-free Laser Firing

When working with micromanipulators, the XYClone allows you to work in "hands-free" mode by using the optional foot switch to fire the laser. Simply use the manipulators to position the embryo to the target and press the foot switch to fire the laser.
Your micromanipulation proceeds rapidly and the time the embryo spends on the microscope stage is minimized. Also, the laser may be fired as many times as required to complete the process, without need of reactivating the laser.

Easy and Fast Zona and Oolemma Ablation

The Flash movie loops below show how easy and fast it is to use the XYClone for zona ablation. (Requires Flash 6 or higher)

Using Manipulators to Position Cell

The first movie loop shows how the XYClone can be operated hands-free while using manipulators to position the ova to drill a hole in the zona to insert an ICSI pipette.
Using Stage Controls to Position Cell

Even when using the stage adjusters to position the embryo for drilling, the process proceeds rapidly. In under 4 seconds, a hole large enough for embryo biospy can be drilled in the zona.
Video footage courtesy of Kathy Mohr, Mutant Mouse Regional Resource Center,
All Rights Reserved
Video footage courtesy of Steven McArthur, Sydney IVF.
All rights reserved.

Frees Your Microscope Ports - Does Not Interfere with Fluorescence

The extremely compact laser unit (just 42mm x 28mm x 54mm) installs directly on turret, leaving both the fluorescence and filter cube ports free for normal use (no removal of components required), and no interference with normal microscope usage.

Unmatched Portability

For a complete laser system, including software and computer, the portability of a XYClone laptop configuration can't be beat. All laser components fit into a custom designed carry case, which offers both protection and easy transport. Combine this with a laptop unit and a small digital camera, and you can literally walk out the door the with a "XYClone To Go!“

Hassle Free Microscope Upgrade or Changeover!!!

The exact same laser configuration installs on ALL brand/model of inverted microscope, including older models. The XYClone (and ZILOS-tk) are ONLY complete laser systems available that can be switched from any brand/model of microscope to any other brand/model of microscope, without need for customization, laser realignment, and possibly even added cost. This means that if you buy any different brand/model microscope in the future, the XYClone can still be used with no changes needed!

Download : Brochure
Download : Specification/Human